Design and Manufacturing of a Simple Plasma Blood Separator Based on Arduino Uno with Servo Motor Drive
Keywords:
arduino, microcontroller, Optocoupler sensor, plasma blood, separatorAbstract
This research aims to design a Plasma Blood Separator that can separate plasma from red blood cells automatical-ly using an Optocoupler sensor and a specimen tube cutter. This sistem is equipped with an Arduino Uno as the microcontroller, a servo motor to clamp the hose, a servo to open the blood bag pressure, a series of push buttons to open the servo, and a buzzer to indicate the completion of separation After testing the Arduino Uno-based Plasma Blood Separator, all functions can work well by showing the results of three experiments that varied the length of the hose. The length of the hose that was varied was 30 cm, 50 cm, 70 cm. The estimated separation time was 20 seconds, 30 seconds, and 40 seconds for mode 1, The estimated separation time was 40 seconds, 60 seconds, and 80 seconds for mode 2, In the results of the measurement of the voltage of the tool, the measurement results were obtained with a small percentage of error with a value of <5% and a high accuracy value with >90%..
References
Drew, V. J., Barro, L., Seghatchian, J., & Burnouf, T. (2017). Towards pathogen inactivation of red blood cells and whole blood targeting viral DNA/RNA: design, technologies, and future prospects for developing countries. Blood Transfusion, 15(6), 512.
Fitzpatrick, J., Bulsara, M. K., McCrory, P. R., Richardson, M. D., & Zheng, M. H. (2017). Analysis of platelet-rich plasma extraction: varia-tions in platelet and blood components between 4 common commercial kits. Orthopaedic journal of sports medicine, 5(1), 2325967116675272. https://doi.org/10.1177/2325967116675272
García-Roa, M., del Carmen Vicente-Ayuso, M., Bobes, A. M., Pedraza, A. C., González-Fernández, A., Martín, M. P., ... & Gutiérrez, L. (2017). Red blood cell storage time and transfusion: current practice, concerns and future perspectives. Blood Transfusion, 15(3), 222.
González, K. M. P., & Gómez-Pastora, J. (2017). Magnetic cell separation: A comprehensive review on the techniques and applications. Journal of Biotechnology, 250, 21-30. https://doi.org/10.1016/j.jbiotec.2017.07.005
González, K. M. P., Tran, L. N. T., Iyer, P. R., Wu, X., Choe, H., Rezaei, B., ... & Gómez-Pastora, J. (2025). Blood cell separation with magnetic techniques: a critical review. Lab on a Chip. https://doi.org/10.1039/D5LC00180C
Halicioglu, R., Dulger, L. C., & Bozdana, A. T. (2016). Mechanisms, classifications, and applications of servo presses: A review with com-parisons. Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, 230(7), 1177-1194. https://doi.org/10.1177/0954405415600013
Lee, K., Han, S., & Lim, S. (2018). Blood transfusion safety and pathogen inactivation: Technological advances and future challenges. Jour-nal of Blood Transfusion, 16(2), 134-142. https://doi.org/10.1182/blood-2018-07-851387
Müller, D., & Lillie, M. (2016). Novel approaches for blood storage and preservation: From red blood cells to platelets. Transfusion Medicine and Hemotherapy, 43(4), 227-235. https://doi.org/10.1159/000447890
Prabhu, G. R. D., & Urban, P. L. (2020). Elevating chemistry research with a modern electronics toolkit. Chemical Reviews, 120(17), 9482-9553. https://doi.org/10.1021/acs.chemrev.0c00206
Roberts, N., James, S., Delaney, M., & Fitzmaurice, C. (2019). The global need and availability of blood products: a modelling study. The Lancet Haematology, 6(12), e606-e615. https://doi.org/10.1016/S2352-3026(19)30200-5
Vemulapati, S., & Erickson, D. (2019). Portable resource-independent blood-plasma separator. Analytical Chemistry, 91(23), 14824-14828. https://doi.org/10.1021/acs.analchem.9b04180
Wang, X., & Kambhampati, R. (2020). Advances in microfluidic devices for blood cell separation. Lab on a Chip, 20(7), 1117-1129. https://doi.org/10.1039/d0lc00100a
Weltmann, K. D., Polak, M., Masur, K., von Woedtke, T., Winter, J., & Reuter, S. (2012). Plasma processes and plasma sources in medi-cine. Contributions to Plasma Physics, 52(7), 644-654. https://doi.org/10.1002/ctpp.201210061
Yu, Y., He, Y., Wen, Y., Zhen, J., & Liu, W. (2012). Low-noise broadband differential optoisolator for Langmuir probes. Journal of Instru-mentation, 7(08), P08018. https://doi.org/10.1088/1748-0221/7/08/P08018
Zhang, X., Zhou, Y., Liu, Z., & Zhang, J. (2020). Recent advances in plasma-based technology for the processing and sterilization of bio-logical materials. Journal of Applied Physics, 128(7), 070902. https://doi.org/10.1063/5.0014729
